Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation.

Granado, Miriam

Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation. [electronic resource] - American journal of physiology. Endocrinology and metabolism Jun 2007 - E1656-65 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0193-1849

10.1152/ajpendo.00502.2006 doi


Animals
Arthritis, Experimental--complications
Cachexia--enzymology
Chronic Disease
Cyclooxygenase 2--metabolism
Cyclooxygenase 2 Inhibitors--pharmacology
Cyclooxygenase Inhibitors--pharmacology
Enzyme Activation
Gene Expression--drug effects
Growth Hormone--genetics
Indomethacin--pharmacology
Insulin-Like Growth Factor Binding Protein 5--genetics
Insulin-Like Growth Factor I--genetics
Liver--metabolism
Male
Meloxicam
Muscle Proteins--genetics
Muscle, Skeletal--enzymology
Pituitary Gland--metabolism
RNA, Messenger--metabolism
Rats
Rats, Wistar
SKP Cullin F-Box Protein Ligases--genetics
Thiazines--pharmacology
Thiazoles--pharmacology
Tripartite Motif Proteins
Tumor Necrosis Factor-alpha--genetics
Ubiquitin-Protein Ligases--genetics
Weight Gain--drug effects