6-Hydroxydopamine induces cystatin C-mediated cysteine protease suppression and cathepsin D activation.

Lee, Daniel C

6-Hydroxydopamine induces cystatin C-mediated cysteine protease suppression and cathepsin D activation. [electronic resource] - Neurochemistry international Mar 2007 - 607-18 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0197-0186

10.1016/j.neuint.2006.12.006 doi


Animals
Caspase 3--drug effects
Cathepsin B--drug effects
Cathepsin D--metabolism
Cell Death--drug effects
Cystatin C
Cystatins--metabolism
Cysteine Endopeptidases--metabolism
Dopamine--metabolism
Down-Regulation--drug effects
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Lysosomes--drug effects
Neurons--drug effects
Neuroprotective Agents--pharmacology
Oxidative Stress--drug effects
Oxidopamine--toxicity
PC12 Cells
Parkinson Disease--enzymology
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases--drug effects
Rats
Sympatholytics--toxicity