Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis.

David, D J

Efficacy of the MCHR1 antagonist N-[3-(1-(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. [electronic resource] - The Journal of pharmacology and experimental therapeutics Apr 2007 - 237-48 p. digital

Publication Type: Journal Article

0022-3565

10.1124/jpet.106.109678 doi


Animals
Anti-Anxiety Agents
Antidepressive Agents
Antidepressive Agents, Tricyclic--metabolism
Antimetabolites
Anxiety--drug therapy
Bromodeoxyuridine
Cell Line, Tumor
Cell Proliferation--drug effects
Citalopram--metabolism
Drug Evaluation, Preclinical
Feeding Behavior--drug effects
Hippocampus--cytology
Imipramine--metabolism
Immunohistochemistry
Male
Mice
Mice, Inbred BALB C
Motor Activity--drug effects
Neurons--drug effects
Piperidines--pharmacology
Receptors, Somatostatin--antagonists & inhibitors
Selective Serotonin Reuptake Inhibitors--metabolism
X-Rays