Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.

Hamid, Shabaz A

Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium. [electronic resource] - American journal of physiology. Heart and circulatory physiology Jun 2007 - H2598-606 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0363-6135

10.1152/ajpheart.01393.2006 doi


1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine--analogs & derivatives
Amides--pharmacology
Androstadienes--pharmacology
Animals
Apoptosis--drug effects
Cardiotonic Agents--pharmacology
Coronary Circulation--drug effects
Cytoskeletal Proteins--metabolism
Enzyme Activation
In Vitro Techniques
Intracellular Signaling Peptides and Proteins--antagonists & inhibitors
Male
Membrane Proteins--metabolism
Microfilament Proteins--metabolism
Multiprotein Complexes--metabolism
Myocardial Infarction--enzymology
Myocardial Reperfusion Injury--enzymology
Myocardium--enzymology
NG-Nitroarginine Methyl Ester--pharmacology
Nitric Oxide--metabolism
Nitric Oxide Synthase Type III--antagonists & inhibitors
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Phosphorylation
Protein Kinase Inhibitors--pharmacology
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins c-akt--metabolism
Pyridines--pharmacology
Rats
Rats, Sprague-Dawley
Signal Transduction--drug effects
Wortmannin
rho-Associated Kinases