TIMP-1 promotes age-related renal fibrosis through upregulating ICAM-1 in human TIMP-1 transgenic mice.

Zhang, Xueguang

TIMP-1 promotes age-related renal fibrosis through upregulating ICAM-1 in human TIMP-1 transgenic mice. [electronic resource] - The journals of gerontology. Series A, Biological sciences and medical sciences Nov 2006 - 1130-43 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1079-5006

10.1093/gerona/61.11.1130 doi


Aging--physiology
Albuminuria
Animals
Collagen Type III--genetics
Collagen Type IV--genetics
Creatinine--blood
Down-Regulation--physiology
Fibrosis
Gene Expression
Genotype
Humans
Intercellular Adhesion Molecule-1--genetics
Kidney--pathology
Macrophages--metabolism
Matrix Metalloproteinase 2--genetics
Matrix Metalloproteinase 9--genetics
Mice
Mice, Transgenic
Models, Animal
RNA, Messenger--metabolism
Tissue Inhibitor of Metalloproteinase-1--genetics
Tissue Inhibitor of Metalloproteinase-2--genetics
Transforming Growth Factor beta1--genetics
Up-Regulation--physiology