In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test.

Hayashi, Makoto

In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test. [electronic resource] - Mutation research Feb 2007 - 10-30 p. digital

Publication Type: Journal Article

0027-5107

10.1016/j.mrgentox.2006.08.010 doi


Animals
Bone Marrow
Cells, Cultured
Dose-Response Relationship, Drug
Erythrocytes--drug effects
Hematopoietic System--cytology
Image Processing, Computer-Assisted
Micronucleus Tests--methods
Rats
Reproducibility of Results
Reticulocytes--cytology