The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis.

Nebert, Daniel W

The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. [electronic resource] - Nature reviews. Cancer Dec 2006 - 947-60 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review

1474-175X

10.1038/nrc2015 doi


Animals
Aryl Hydrocarbon Hydroxylases--metabolism
Biotransformation
Carcinogens, Environmental--pharmacokinetics
Cell Transformation, Neoplastic--drug effects
Cytochrome P-450 CYP1A1--metabolism
Cytochrome P-450 CYP1A2--metabolism
Cytochrome P-450 CYP1B1
Cytochrome P-450 Enzyme System--genetics
DNA-Binding Proteins--metabolism
Gene Expression Regulation, Enzymologic
Humans
Isoenzymes--genetics
Metabolic Networks and Pathways
Mice
Models, Biological
Neoplasms--chemically induced
Pharmacogenetics
Receptors, Aryl Hydrocarbon--metabolism
Receptors, Cytoplasmic and Nuclear--metabolism
Risk Assessment
Risk Factors
Signal Transduction
Transcription Factors--metabolism