T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2.

Dong, Shen

T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2. [electronic resource] - The Journal of experimental medicine Oct 2006 - 2509-18 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-1007

10.1084/jem.20060650 doi


Adaptor Proteins, Signal Transducing--biosynthesis
Cell Line, Tumor
DNA-Binding Proteins--physiology
Down-Regulation--immunology
Feedback, Physiological--immunology
GRB2 Adaptor Protein--physiology
Humans
Inositol Polyphosphate 5-Phosphatases
Jurkat Cells
Ligands
Lymphocyte Activation
Membrane Proteins--biosynthesis
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
Phosphoproteins--physiology
Phosphoric Monoester Hydrolases--physiology
Phosphorylation
RNA-Binding Proteins--physiology
Receptor-CD3 Complex, Antigen, T-Cell--metabolism
Signal Transduction--immunology
Tyrosine--metabolism