Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model.

Silliman, Christopher C

Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model. [electronic resource] - Blood Feb 2007 - 1752-5 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0006-4971

10.1182/blood-2006-05-025106 doi


Blood Donors
Cell Survival
Coculture Techniques
Cytotoxicity, Immunologic
Endothelial Cells--cytology
Endothelium, Vascular--pathology
Humans
Isoantibodies--immunology
Isoantigens--immunology
Neutrophil Activation--immunology
Neutrophils--cytology
Pulmonary Circulation
Respiratory Burst
Respiratory Distress Syndrome--etiology
Transfusion Reaction