Synthesis and immunobiological activity of an original series of acyclic lipid a mimics based on a pseudodipeptide backbone.

Martin, Olivier R

Synthesis and immunobiological activity of an original series of acyclic lipid a mimics based on a pseudodipeptide backbone. [electronic resource] - Journal of medicinal chemistry Oct 2006 - 6000-14 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm060482a doi


Adjuvants, Immunologic--chemical synthesis
Animals
Cells, Cultured
Dipeptides--chemistry
Escherichia coli
Fatty Acids--chemistry
Homoserine--analogs & derivatives
Humans
Interleukin-6--antagonists & inhibitors
Leukocytes, Mononuclear--drug effects
Lipid A--chemistry
Lipopolysaccharides--pharmacology
Macrophages--drug effects
Male
Mice
Mice, Inbred C57BL
Molecular Mimicry
Nitric Oxide--biosynthesis
Organophosphates--chemical synthesis
Stereoisomerism
Structure-Activity Relationship