Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity.

Sterba, Martin

Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity. [electronic resource] - The Journal of pharmacology and experimental therapeutics Dec 2006 - 1336-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3565

10.1124/jpet.106.111468 doi


Animals
Antibiotics, Antineoplastic
Blood Pressure--drug effects
Body Weight--drug effects
Cardiac Output--drug effects
Cardiotonic Agents
Cell Division--drug effects
Chinchilla
Daunorubicin
Electrocardiography--drug effects
HL-60 Cells
Heart Diseases--chemically induced
Heart Rate--drug effects
Humans
Hydrazones--pharmacology
Iron Chelating Agents--pharmacology
Male
Myocardial Contraction--drug effects
Myocardium--metabolism
Pyridoxal--analogs & derivatives
Rabbits
Stroke Volume--drug effects
Troponin T--metabolism
Ventricular Function, Left--drug effects