The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation.
Schluenzen, Frank
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. [electronic resource] - Nature structural & molecular biology Oct 2006 - 871-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1545-9993
10.1038/nsmb1145 doi
Aminoglycosides--chemistry
Anti-Bacterial Agents--chemistry
Binding Sites
Codon
Escherichia coli--chemistry
Models, Molecular
Nucleotides--chemistry
Peptide Chain Initiation, Translational
Protein Structure, Tertiary
RNA, Bacterial--chemistry
RNA, Messenger--chemistry
RNA, Transfer--chemistry
Structure-Activity Relationship
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. [electronic resource] - Nature structural & molecular biology Oct 2006 - 871-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1545-9993
10.1038/nsmb1145 doi
Aminoglycosides--chemistry
Anti-Bacterial Agents--chemistry
Binding Sites
Codon
Escherichia coli--chemistry
Models, Molecular
Nucleotides--chemistry
Peptide Chain Initiation, Translational
Protein Structure, Tertiary
RNA, Bacterial--chemistry
RNA, Messenger--chemistry
RNA, Transfer--chemistry
Structure-Activity Relationship