Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.

Oikonomakos, Nikos G

Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. [electronic resource] - Journal of medicinal chemistry Sep 2006 - 5687-701 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm060496g doi


Animals
Catalytic Domain
Crystallography, X-Ray
Glucosephosphates--chemistry
Glycogen Phosphorylase--antagonists & inhibitors
Glycogenolysis
Imino Sugars--chemical synthesis
Kinetics
Liver--enzymology
Models, Molecular
Protein Binding
Protein Conformation
Rabbits
Stereoisomerism
Structure-Activity Relationship