Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1).

Lee, Jongsung

Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1). [electronic resource] - Life sciences Nov 2006 - 2480-5 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0024-3205

10.1016/j.lfs.2006.08.008 doi


Anthracenes--pharmacology
Blotting, Western
Cells, Cultured
Dose-Response Relationship, Drug
Emodin--pharmacology
Fibroblasts--cytology
Flavonoids--pharmacology
Humans
Imidazoles--pharmacology
Infant, Newborn
JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors
Luciferases--genetics
Male
Matrix Metalloproteinase 1--biosynthesis
Mitogen-Activated Protein Kinase 1--antagonists & inhibitors
Mitogen-Activated Protein Kinase 3--antagonists & inhibitors
Phosphorylation--drug effects
Promoter Regions, Genetic--genetics
Pyridines--pharmacology
Rheum--chemistry
Transcription Factor AP-1--antagonists & inhibitors
Transfection
Tumor Necrosis Factor-alpha--pharmacology
p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors