HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway.

Laezza, Chiara

HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. [electronic resource] - Journal of molecular medicine (Berlin, Germany) Nov 2006 - 967-73 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0946-2716

10.1007/s00109-006-0079-8 doi


Animals
Disease Models, Animal
Extracellular Signal-Regulated MAP Kinases--metabolism
Flavonoids--pharmacology
Gene Transfer Techniques
Goiter--chemically induced
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Hyperplasia
Hypertrophy
Lovastatin--pharmacology
MAP Kinase Signaling System--drug effects
Male
Phosphorylation
Proliferating Cell Nuclear Antigen--analysis
Propylthiouracil
Protein Kinase Inhibitors--pharmacology
Protein Prenylation--drug effects
Rats
Rats, Wistar
Terpenes--metabolism
Thyroid Gland--drug effects
Thyrotropin--blood
ras Proteins--genetics