Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis.

Paintlia, Ajaib S

Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis. [electronic resource] - The American journal of pathology Sep 2006 - 1012-25 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0002-9440

10.2353/ajpath.2006.051309 doi


AMP-Activated Protein Kinases
Aminoimidazole Carboxamide--administration & dosage
Animals
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Drug Therapy, Combination
Encephalomyelitis, Autoimmune, Experimental--drug therapy
Enzyme Activation--drug effects
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--administration & dosage
Hypoglycemic Agents--administration & dosage
Immunoglobulin G--immunology
Immunologic Factors--administration & dosage
Lovastatin--administration & dosage
Multienzyme Complexes--immunology
Multiple Sclerosis--drug therapy
Myelin Basic Protein--immunology
Protein Serine-Threonine Kinases--immunology
Rats
Rats, Inbred Lew
Ribonucleotides--administration & dosage
Th1 Cells--immunology
Th2 Cells--immunology