Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents.

Leger, D Y

Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents. [electronic resource] - Apoptosis : an international journal on programmed cell death Oct 2006 - 1747-60 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1360-8185

10.1007/s10495-006-9439-7 doi


Antineoplastic Agents--therapeutic use
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Caspase 3--metabolism
Cell Proliferation--drug effects
Cell Survival--drug effects
DNA Fragmentation--drug effects
Dose-Response Relationship, Drug
Enzyme Activation--drug effects
Etoposide--analogs & derivatives
Humans
Isoxazoles--pharmacology
K562 Cells
Leflunomide
Leukemia, Erythroblastic, Acute--drug therapy
MAP Kinase Kinase 4--metabolism
MAP Kinase Signaling System--drug effects
Mitogen-Activated Protein Kinase 8--metabolism
NF-kappa B--metabolism
Organophosphorus Compounds--pharmacology
Phosphatidylinositol 3-Kinases--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Signal Transduction--drug effects
Staurosporine--pharmacology
p38 Mitogen-Activated Protein Kinases--metabolism