Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration.

Nagel, Jens

Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration. [electronic resource] - Neuropharmacology Dec 2006 - 1163-71 p. digital

Publication Type: Journal Article

0028-3908

10.1016/j.neuropharm.2006.07.018 doi


Analgesics, Non-Narcotic--administration & dosage
Animals
Biotransformation--drug effects
Blood-Brain Barrier
Brain Chemistry--drug effects
Chronic Disease
Dipeptides--analysis
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Extracellular Fluid--chemistry
Glutamate Carboxypeptidase II--antagonists & inhibitors
Injections, Intraperitoneal
Ligation
Male
Microdialysis
Models, Animal
Neuralgia--drug therapy
Neuroprotective Agents--administration & dosage
Organophosphorus Compounds--administration & dosage
Pain Threshold--drug effects
Pyridazines--pharmacology
Quinolines--pharmacology
Rats
Rats, Sprague-Dawley
Rats, Wistar
Receptors, Metabotropic Glutamate--antagonists & inhibitors
Sciatic Nerve--injuries