Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase.
Smith, Leon
Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase. [electronic resource] - Bioorganic & medicinal chemistry letters Oct 2006 - 5102-6 p. digital
Publication Type: Journal Article
0960-894X
10.1016/j.bmcl.2006.07.031 doi
Antineoplastic Agents--chemical synthesis
Azepines--chemical synthesis
Cell Line, Tumor
ErbB Receptors--antagonists & inhibitors
Heterocyclic Compounds, 3-Ring--chemical synthesis
Humans
Inhibitory Concentration 50
Neoplasm Proteins--antagonists & inhibitors
Phosphorylation--drug effects
Structure-Activity Relationship
Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors
Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase. [electronic resource] - Bioorganic & medicinal chemistry letters Oct 2006 - 5102-6 p. digital
Publication Type: Journal Article
0960-894X
10.1016/j.bmcl.2006.07.031 doi
Antineoplastic Agents--chemical synthesis
Azepines--chemical synthesis
Cell Line, Tumor
ErbB Receptors--antagonists & inhibitors
Heterocyclic Compounds, 3-Ring--chemical synthesis
Humans
Inhibitory Concentration 50
Neoplasm Proteins--antagonists & inhibitors
Phosphorylation--drug effects
Structure-Activity Relationship
Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors