Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin.

Takeda, Naoya

Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. [electronic resource] - American journal of respiratory cell and molecular biology Dec 2006 - 722-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1044-1549

10.1165/rcmb.2006-0034OC doi


ADP Ribose Transferases--pharmacology
Alkyl and Aryl Transferases--antagonists & inhibitors
Amides--pharmacology
Anti-Asthmatic Agents--pharmacology
Botulinum Toxins--pharmacology
Bronchi--drug effects
Cell Membrane--drug effects
Cell Proliferation--drug effects
Cells, Cultured
DNA--biosynthesis
Dose-Response Relationship, Drug
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Extracellular Signal-Regulated MAP Kinases--metabolism
Humans
Intracellular Signaling Peptides and Proteins--antagonists & inhibitors
Leucine--analogs & derivatives
Mitogens--pharmacology
Muscle, Smooth--drug effects
Phosphorylation
Protein Prenylation--drug effects
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins c-akt--metabolism
Pyridines--pharmacology
Simvastatin--pharmacology
Terpenes--pharmacology
cdc42 GTP-Binding Protein--metabolism
rac1 GTP-Binding Protein--metabolism
rho-Associated Kinases
rhoA GTP-Binding Protein--antagonists & inhibitors