Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development.

Yu, Lei

Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development. [electronic resource] - Journal of pharmaceutical and biomedical analysis Oct 2006 - 455-63 p. digital

Publication Type: Comparative Study; Journal Article

0731-7085

10.1016/j.jpba.2006.05.008 doi


Amino Acid Sequence
Antibodies, Monoclonal--chemistry
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Cyclization
Drug Stability
Excipients--chemistry
Glutamic Acid--chemistry
Hydrogen-Ion Concentration
Kinetics
Molecular Sequence Data
Protein Conformation
Protein Denaturation
Pyrrolidonecarboxylic Acid--chemistry
Recombinant Proteins--chemistry
Spectrometry, Mass, Electrospray Ionization--methods
Surface-Active Agents--chemistry
Temperature