Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis.
Hirsh, Andrew J
Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. [electronic resource] - Journal of medicinal chemistry Jul 2006 - 4098-115 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm051134w doi
Animals
Bronchi--drug effects
Bronchitis, Chronic--drug therapy
Combinatorial Chemistry Techniques
Cystic Fibrosis--drug therapy
Dogs
Epithelial Sodium Channels
Guanidines--chemical synthesis
Models, Molecular
Pyrazines--chemical synthesis
Respiratory Mucosa--drug effects
Sodium Channel Blockers--chemical synthesis
Sodium Channels--drug effects
Stereoisomerism
Structure-Activity Relationship
Tissue Culture Techniques
Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. [electronic resource] - Journal of medicinal chemistry Jul 2006 - 4098-115 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm051134w doi
Animals
Bronchi--drug effects
Bronchitis, Chronic--drug therapy
Combinatorial Chemistry Techniques
Cystic Fibrosis--drug therapy
Dogs
Epithelial Sodium Channels
Guanidines--chemical synthesis
Models, Molecular
Pyrazines--chemical synthesis
Respiratory Mucosa--drug effects
Sodium Channel Blockers--chemical synthesis
Sodium Channels--drug effects
Stereoisomerism
Structure-Activity Relationship
Tissue Culture Techniques