Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.

Cover, Cathleen

Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. [electronic resource] - Toxicology and applied pharmacology Oct 2006 - 98-107 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

0041-008X

10.1016/j.taap.2006.04.010 doi


Acetaminophen--toxicity
Acute Disease
Alanine Transaminase--blood
Analgesics, Non-Narcotic--toxicity
Animals
Chemical and Drug Induced Liver Injury--blood
Female
Gene Expression--drug effects
Inflammation--chemically induced
Intercellular Adhesion Molecule-1--genetics
Interleukin-1beta--genetics
Liver--drug effects
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Knockout
Neutrophil Infiltration--drug effects
Poly (ADP-Ribose) Polymerase-1
Poly Adenosine Diphosphate Ribose--metabolism
Poly(ADP-ribose) Polymerases--metabolism
RNA, Messenger--genetics
Reverse Transcriptase Polymerase Chain Reaction
Species Specificity
Tumor Necrosis Factor-alpha--genetics