ABCB1 modulation does not circumvent drug extrusion from primitive leukemic progenitor cells and may preferentially target residual normal cells in acute myelogenous leukemia.

Raaijmakers, Marc H G P

ABCB1 modulation does not circumvent drug extrusion from primitive leukemic progenitor cells and may preferentially target residual normal cells in acute myelogenous leukemia. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Jun 2006 - 3452-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1078-0432

10.1158/1078-0432.CCR-05-1945 doi


ADP-ribosyl Cyclase 1--analysis
ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1--drug effects
Adolescent
Adult
Aged
Antigens, CD34--biosynthesis
Antigens, Differentiation--biosynthesis
Biological Transport--drug effects
Bone Marrow Cells--drug effects
Cyclosporins--pharmacology
Drug Resistance, Multiple
Female
Flow Cytometry
Hematopoietic Stem Cells--drug effects
Humans
Leukemia, Myeloid, Acute--drug therapy
Male
Middle Aged
Mitoxantrone--antagonists & inhibitors
Oncogene Proteins, Fusion--biosynthesis
Reverse Transcriptase Polymerase Chain Reaction--methods
Verapamil--pharmacology