Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen.

Wood-Allum, Clare A

Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. [electronic resource] - Brain : a journal of neurology Jul 2006 - 1693-709 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1460-2156

10.1093/brain/awl118 doi


Animals
Antioxidants--metabolism
Azoles--pharmacology
Blotting, Western--methods
Cell Death--drug effects
Cells, Cultured
Down-Regulation
Electrophoresis, Polyacrylamide Gel--methods
Humans
Isoindoles
Mice
Mice, Transgenic
Mitochondria--metabolism
Mitochondrial Diseases--genetics
Motor Neuron Disease--genetics
Neoplasm Proteins--metabolism
Organoselenium Compounds--pharmacology
Oxidative Stress--drug effects
Peroxidases--metabolism
Peroxiredoxin III
Peroxiredoxins
Polymerase Chain Reaction--methods
Proteomics
Response Elements--drug effects
Spinal Cord--metabolism
Superoxide Dismutase--genetics
Superoxide Dismutase-1