TGF-beta1-induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells.

McGillicuddy, Fiona C

TGF-beta1-induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells. [electronic resource] - Vascular pharmacology Jun 2006 - 469-75 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1537-1891

10.1016/j.vph.2006.03.002 doi


Adult
Cells, Cultured
Coronary Restenosis--prevention & control
Coronary Vessels--drug effects
Dose-Response Relationship, Drug
Enzyme Inhibitors--pharmacology
Fatty Acids, Monounsaturated--pharmacology
Fluvastatin
Gene Expression Regulation
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Imidazoles--pharmacology
Indoles--pharmacology
MAP Kinase Signaling System
Male
Muscle, Smooth, Vascular--drug effects
Myocytes, Smooth Muscle--drug effects
Phosphorylation
Pyridines--pharmacology
RNA, Messenger--metabolism
Thrombospondin 1--genetics
Transforming Growth Factor beta--pharmacology
Transforming Growth Factor beta1
p38 Mitogen-Activated Protein Kinases--metabolism