Induction of cytokine expression by herpes simplex virus in human monocyte-derived macrophages and dendritic cells is dependent on virus replication and is counteracted by ICP27 targeting NF-kappaB and IRF-3.

Melchjorsen, Jesper

Induction of cytokine expression by herpes simplex virus in human monocyte-derived macrophages and dendritic cells is dependent on virus replication and is counteracted by ICP27 targeting NF-kappaB and IRF-3. [electronic resource] - The Journal of general virology May 2006 - 1099-1108 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-1317

10.1099/vir.0.81541-0 doi


Cytokines--biosynthesis
Dendritic Cells--immunology
Gene Expression Regulation
Herpesvirus 1, Human--genetics
Humans
Immediate-Early Proteins--genetics
Interferon Regulatory Factor-3--metabolism
Interferon-alpha--pharmacology
Interferons
Interleukins--pharmacology
Macrophages--immunology
Mutation
NF-kappa B--metabolism
Trans-Activators--genetics
Transcription Factors--genetics
Ubiquitin-Protein Ligases--genetics
Viral Interference
Virus Replication