Truncation mutation in HRG4 (UNC119) leads to mitochondrial ANT-1-mediated photoreceptor synaptic and retinal degeneration by apoptosis.

Mori, Naoki

Truncation mutation in HRG4 (UNC119) leads to mitochondrial ANT-1-mediated photoreceptor synaptic and retinal degeneration by apoptosis. [electronic resource] - Investigative ophthalmology & visual science Apr 2006 - 1281-92 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0146-0404

10.1167/iovs.05-0493 doi


Adaptor Proteins, Signal Transducing
Adenine Nucleotide Translocator 1--deficiency
Animals
Apoptosis
Blotting, Western
Caspase 3
Caspases--metabolism
Codon, Nonsense
Cytochromes c--metabolism
Enzyme Activation
In Situ Nick-End Labeling
Intracellular Signaling Peptides and Proteins--genetics
Mice
Mice, Transgenic
Microscopy, Fluorescence
Microtubule Proteins--genetics
Mitochondria--metabolism
Photoreceptor Cells, Vertebrate--metabolism
Retinal Degeneration--genetics
Synapses--metabolism