Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning.

Kellendonk, Christoph

Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. [electronic resource] - Neuron Feb 2006 - 603-15 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0896-6273

10.1016/j.neuron.2006.01.023 doi


Adenylyl Cyclases--metabolism
Analysis of Variance
Animals
Behavior, Animal--physiology
Carbon Isotopes--pharmacokinetics
Cognition Disorders--genetics
Corpus Striatum--metabolism
Deoxyglucose--pharmacokinetics
Disease Models, Animal
Dopamine Agonists--pharmacology
Dopamine Antagonists--pharmacokinetics
Dose-Response Relationship, Drug
Doxycycline--pharmacology
Excitatory Amino Acid Agonists--toxicity
Gene Expression--drug effects
Glucose--metabolism
Humans
Immunohistochemistry--methods
In Situ Hybridization--methods
Male
Memory, Short-Term--physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
N-Methylaspartate--toxicity
Prefrontal Cortex--abnormalities
Protein Binding--drug effects
Proto-Oncogene Proteins c-fos--metabolism
Radioligand Assay--methods
Reaction Time--genetics
Receptors, Dopamine D2--genetics
Spiperone--pharmacokinetics
Time Factors
Tritium--pharmacokinetics