Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm.

Liu, Zaiping

Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm. [electronic resource] - The Journal of biological chemistry May 2006 - 14738-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M508664200 doi


Animals
Anoikis
Apoptosis
Caspase 9
Caspases--metabolism
Cytoplasm--metabolism
Epithelial Cells--cytology
Fibroblasts--metabolism
High-Temperature Requirement A Serine Peptidase 2
Intestinal Mucosa--metabolism
Mice
Mitochondria--metabolism
Mitochondrial Proteins
Oncogene Protein p21(ras)--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Serine Endopeptidases--metabolism
bcl-X Protein--metabolism