The G972R variant of the insulin receptor substrate-1 gene impairs insulin signaling and cell differentiation in 3T3L1 adipocytes; treatment with a PPARgamma agonist restores normal cell signaling and differentiation.
Sentinelli, F
The G972R variant of the insulin receptor substrate-1 gene impairs insulin signaling and cell differentiation in 3T3L1 adipocytes; treatment with a PPARgamma agonist restores normal cell signaling and differentiation. [electronic resource] - The Journal of endocrinology Feb 2006 - 271-85 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-0795
10.1677/joe.1.06290 doi
3T3 Cells
Adipocytes--drug effects
Animals
Cell Differentiation--drug effects
Humans
Hypoglycemic Agents--pharmacology
Insulin--metabolism
Insulin Receptor Substrate Proteins
Mice
Mitogen-Activated Protein Kinases--metabolism
Mutation
PPAR gamma--agonists
Phosphatidylinositol 3-Kinases--metabolism
Phosphoproteins--genetics
Phosphorylation
Pioglitazone
Serine--metabolism
Signal Transduction--drug effects
Thiazolidinediones--pharmacology
Threonine--metabolism
Transfection
Tyrosine--metabolism
The G972R variant of the insulin receptor substrate-1 gene impairs insulin signaling and cell differentiation in 3T3L1 adipocytes; treatment with a PPARgamma agonist restores normal cell signaling and differentiation. [electronic resource] - The Journal of endocrinology Feb 2006 - 271-85 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-0795
10.1677/joe.1.06290 doi
3T3 Cells
Adipocytes--drug effects
Animals
Cell Differentiation--drug effects
Humans
Hypoglycemic Agents--pharmacology
Insulin--metabolism
Insulin Receptor Substrate Proteins
Mice
Mitogen-Activated Protein Kinases--metabolism
Mutation
PPAR gamma--agonists
Phosphatidylinositol 3-Kinases--metabolism
Phosphoproteins--genetics
Phosphorylation
Pioglitazone
Serine--metabolism
Signal Transduction--drug effects
Thiazolidinediones--pharmacology
Threonine--metabolism
Transfection
Tyrosine--metabolism