Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease.

Low, Seng Hui

Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. [electronic resource] - Developmental cell Jan 2006 - 57-69 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1534-5807

10.1016/j.devcel.2005.12.005 doi


Amino Acid Sequence
Animals
Blotting, Northern--methods
Blotting, Western--methods
Cell Line
Cilia--drug effects
Dose-Response Relationship, Drug
Embryo, Mammalian
Embryo, Nonmammalian
Endonucleases
Enzyme Activation--physiology
Epithelium--drug effects
Fluorescent Antibody Technique--methods
Gene Expression--physiology
Gene Expression Regulation--drug effects
Humans
Immunoprecipitation--methods
Interleukin-4--pharmacology
Kidney--metabolism
Luciferases--metabolism
Mechanotransduction, Cellular--physiology
Models, Biological
Molecular Biology--methods
Mutagenesis--physiology
Nuclear Proteins--metabolism
Polycystic Kidney, Autosomal Dominant--metabolism
Protein Binding
Protein Structure, Tertiary
Proteins--physiology
STAT6 Transcription Factor--metabolism
TRPP Cation Channels
Trans-Activators--physiology
Transfection--methods
Translocation, Genetic
Zebrafish