Hydrogen peroxide causes uncoupling of dopamine D1-like receptors from G proteins via a mechanism involving protein kinase C and G-protein-coupled receptor kinase 2.

Asghar, Mohammad

Hydrogen peroxide causes uncoupling of dopamine D1-like receptors from G proteins via a mechanism involving protein kinase C and G-protein-coupled receptor kinase 2. [electronic resource] - Free radical biology & medicine Jan 2006 - 13-20 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0891-5849

10.1016/j.freeradbiomed.2005.08.018 doi


2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine--pharmacology
Animals
Dopamine Agonists--pharmacology
Enzyme Inhibitors--pharmacology
G-Protein-Coupled Receptor Kinase 2
Guanosine 5'-O-(3-Thiotriphosphate)--metabolism
Hydrogen Peroxide--pharmacology
Kidney Tubules, Proximal--drug effects
Malondialdehyde--metabolism
Oxidants--pharmacology
Oxidative Stress
Phorbol Esters--pharmacology
Phosphorylation--drug effects
Protein Kinase C--metabolism
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1--metabolism
Serine--metabolism
Sodium-Potassium-Exchanging ATPase--antagonists & inhibitors
beta-Adrenergic Receptor Kinases--antagonists & inhibitors