Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

Napper, Andrew D

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. [electronic resource] - Journal of medicinal chemistry Dec 2005 - 8045-54 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm050522v doi


Animals
Biological Availability
CHO Cells
Carbazoles--chemical synthesis
Cell Membrane Permeability
Cricetinae
Cricetulus
Drug Stability
Fluorometry
Histone Deacetylase Inhibitors
Histone Deacetylases--chemistry
Humans
In Vitro Techniques
Indoles--chemical synthesis
Kinetics
Mice
Mice, Inbred C57BL
Microsomes, Liver--metabolism
NAD--chemistry
NAD+ Nucleosidase--chemistry
Niacinamide--chemistry
Rats
Recombinant Proteins--antagonists & inhibitors
Sirtuin 1
Sirtuins--antagonists & inhibitors
Stereoisomerism
Structure-Activity Relationship