Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.

Falgueyret, Jean-Pierre

Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. [electronic resource] - Journal of medicinal chemistry Dec 2005 - 7535-43 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm0504961 doi


Animals
Antigen Presentation--drug effects
Autoradiography
Benzamides--chemistry
Bone Density Conservation Agents--chemistry
Cathepsin B--antagonists & inhibitors
Cathepsin K
Cathepsin L
Cathepsins--antagonists & inhibitors
Cell Line
Cysteine Endopeptidases
Female
Humans
Lysosomes--drug effects
Mice
Mice, Inbred C57BL
Morpholines--chemistry
Piperazines--chemistry
Rabbits
Rats
Structure-Activity Relationship
Thiazoles--chemistry
Tissue Distribution