Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice.

Lau, Paul P

Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice. [electronic resource] - Arteriosclerosis, thrombosis, and vascular biology Jan 2006 - 143-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1524-4636

10.1161/01.ATV.0000193510.19000.10 doi


Animals
Aorta--drug effects
Atherosclerosis--chemically induced
Chemokine CXCL1
Chemokines
Chemokines, CXC
Cyclooxygenase 2--genetics
Cytokines--blood
Disease Models, Animal
Gene Expression--drug effects
Hypercholesterolemia--genetics
Interleukin-1--blood
Macrophages, Peritoneal--drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
NF-kappa B--metabolism
Nicotine--pharmacology
Nicotinic Agonists--pharmacology
Nitric Oxide Synthase Type II--genetics
Proto-Oncogene Proteins c-sis--genetics
Receptors, LDL--genetics
Tumor Necrosis Factor-alpha--metabolism
Vascular Cell Adhesion Molecule-1--genetics