A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression.

Caligiuri, Maureen

A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. [electronic resource] - Chemistry & biology Oct 2005 - 1103-15 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1074-5521

10.1016/j.chembiol.2005.08.008 doi


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle
Cell Line, Tumor
Cyclin-Dependent Kinases--antagonists & inhibitors
Drug Screening Assays, Antitumor
HCT116 Cells
Humans
Intracellular Signaling Peptides and Proteins--classification
Proteome--drug effects
Pyrimidines--classification