Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release.

Yaksh, Tony L

Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. [electronic resource] - The Journal of pharmacology and experimental therapeutics Jan 2006 - 466-75 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3565

10.1124/jpet.105.091686 doi


Animals
Carrageenan
Chemical Phenomena
Chemistry, Physical
Cyclooxygenase Inhibitors--pharmacology
Dinoprostone--metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors--administration & dosage
Hot Temperature
Hyperalgesia--chemically induced
Injections, Intraperitoneal
Injections, Spinal
Male
Microdialysis
Oxidation-Reduction
Phospholipases A--antagonists & inhibitors
Phospholipases A2
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1--antagonists & inhibitors
Spinal Cord--drug effects
Substance P
gamma-Aminobutyric Acid--administration & dosage