Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells.

Bilancio, Antonio

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. [electronic resource] - Blood Jan 2006 - 642-50 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0006-4971

10.1182/blood-2005-07-3041 doi


Animals
Apoptosis
B-Lymphocytes--metabolism
Calcium--metabolism
Cell Cycle
Cell Differentiation
Cell Proliferation--drug effects
Class I Phosphatidylinositol 3-Kinases
Cyclin A--metabolism
Cyclin D2
Cyclin E--metabolism
Cyclins--metabolism
Enzyme Inhibitors--pharmacology
Extracellular Signal-Regulated MAP Kinases--metabolism
Female
Forkhead Box Protein O3
Forkhead Transcription Factors--metabolism
Glycogen Synthase Kinase 3--metabolism
Glycogen Synthase Kinase 3 beta
Interleukin-4--pharmacology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Phosphatidylinositol 3-Kinases--genetics
Phosphorylation
Protein Isoforms
Proto-Oncogene Proteins c-akt--metabolism
Receptors, Antigen, B-Cell--metabolism
Receptors, Interleukin-4--metabolism
Retinoblastoma Protein--metabolism
Ribosomal Protein S6 Kinases, 70-kDa--metabolism
Signal Transduction