3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells.

Poeckel, Daniel

3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells. [electronic resource] - The Journal of pharmacology and experimental therapeutics Jan 2006 - 224-32 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3565

10.1124/jpet.105.089466 doi


Anti-Inflammatory Agents
Blotting, Western
Calcium--metabolism
Calcium Channel Agonists--pharmacology
Cell Line
Cell Membrane--drug effects
Electrophoresis, Polyacrylamide Gel
Enzyme Activation--drug effects
Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors
Humans
In Vitro Techniques
Inosine Triphosphate--metabolism
Mitogen-Activated Protein Kinases--metabolism
Monocytes--drug effects
N-Formylmethionine Leucyl-Phenylalanine--pharmacology
Neutrophils--drug effects
Platelet Activating Factor--pharmacology
Triterpenes--pharmacology
p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors