Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.

Ota, H

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. [electronic resource] - Oncogene Jan 2006 - 176-85 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0950-9232

10.1038/sj.onc.1209049 doi


Benzamides--pharmacology
Breast Neoplasms--drug therapy
Cellular Senescence--drug effects
Enzyme Activation--drug effects
Epidermal Growth Factor--pharmacology
ErbB Receptors--metabolism
Genes, ras--physiology
Histone Deacetylase Inhibitors
Humans
Insulin-Like Growth Factor I--pharmacology
Lung Neoplasms--drug therapy
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Naphthols--pharmacology
Phosphatidylinositol 3-Kinases--metabolism
Phosphorylation--drug effects
Plasminogen Activator Inhibitor 1--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Receptor, IGF Type 1--metabolism
Signal Transduction--drug effects
Sirtuin 1
Sirtuins--antagonists & inhibitors
Tumor Cells, Cultured
Tyrosine--metabolism
beta-Galactosidase--metabolism
p38 Mitogen-Activated Protein Kinases--metabolism