Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.

Peretto, Ilaria

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. [electronic resource] - Journal of medicinal chemistry Sep 2005 - 5705-20 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm0502541 doi


Administration, Oral
Alzheimer Disease--blood
Amyloid beta-Peptides--antagonists & inhibitors
Animals
Anti-Inflammatory Agents, Non-Steroidal--chemical synthesis
Blood-Brain Barrier--metabolism
Caco-2 Cells
Cell Line, Tumor
Cell Membrane Permeability
Cyclooxygenase Inhibitors--pharmacology
Flurbiprofen--analogs & derivatives
Glioma
Humans
Immunoassay
In Vitro Techniques
Injections, Intravenous
Mice
Mice, Transgenic
Peptide Fragments--antagonists & inhibitors
Rats
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Stereoisomerism
Structure-Activity Relationship