Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage.

Yuan, Yu-Ren

Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. [electronic resource] - Molecular cell Aug 2005 - 405-19 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1097-2765

10.1016/j.molcel.2005.07.011 doi


Amino Acid Sequence
Argonaute Proteins
Bacteria--enzymology
Bacterial Proteins--chemistry
Binding Sites--genetics
Catalytic Domain--genetics
Cations, Divalent--chemistry
Crystallography, X-Ray
DNA, Single-Stranded--metabolism
Endoribonucleases--chemistry
Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factors--genetics
Humans
Models, Chemical
Models, Molecular
Molecular Sequence Data
Oligonucleotides--metabolism
Peptide Initiation Factors--genetics
Protein Binding
Protein Conformation
Protein Structure, Tertiary
RNA, Double-Stranded--metabolism
RNA, Messenger--metabolism
RNA-Induced Silencing Complex--metabolism
Recombinant Fusion Proteins--metabolism
Recombinant Proteins--chemistry
Sequence Homology, Amino Acid
Static Electricity