Sildenafil inhibits the formation of superoxide and the expression of gp47 NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells.

Koupparis, Anthony J

Sildenafil inhibits the formation of superoxide and the expression of gp47 NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells. [electronic resource] - BJU international Aug 2005 - 423-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1464-4096

10.1111/j.1464-410X.2005.05643.x doi


15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid--pharmacology
Animals
Erectile Dysfunction--metabolism
Male
Muscle, Smooth, Vascular--metabolism
NADPH Oxidases--metabolism
Penis--metabolism
Piperazines--pharmacology
Purines
Rats
Sildenafil Citrate
Sulfones
Superoxides--metabolism
Thromboxane A2
Vasoconstrictor Agents--pharmacology