The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.

Basso, Andrea D

The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity. [electronic resource] - The Journal of biological chemistry Sep 2005 - 31101-8 p. digital

Publication Type: Journal Article

0021-9258

10.1074/jbc.M503763200 doi


Alkyl and Aryl Transferases--antagonists & inhibitors
Animals
Antineoplastic Agents--therapeutic use
Bridged-Ring Compounds--therapeutic use
Caspases--metabolism
Cell Line, Tumor
Farnesyltranstransferase
Humans
Monomeric GTP-Binding Proteins--genetics
Neoplasms--drug therapy
Neuropeptides--genetics
Phosphorylation
Piperidines--metabolism
Protein Kinases--genetics
Protein Prenylation
Pyridines--metabolism
RNA, Messenger--metabolism
Ras Homolog Enriched in Brain Protein
Recombinant Fusion Proteins--genetics
Signal Transduction--physiology
TOR Serine-Threonine Kinases
Tamoxifen--therapeutic use
Taxoids--therapeutic use