Rational design of shepherdin, a novel anticancer agent.

Plescia, Janet

Rational design of shepherdin, a novel anticancer agent. [electronic resource] - Cancer cell May 2005 - 457-68 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1535-6108

10.1016/j.ccr.2005.03.035 doi


Adenosine Triphosphate--metabolism
Animals
Antennapedia Homeodomain Protein
Antimetabolites, Antineoplastic--chemistry
Apoptosis--drug effects
Benzoquinones
Binding Sites--genetics
Breast Neoplasms--drug therapy
Cell Line, Tumor
Cell Survival--drug effects
Cytochromes c--metabolism
Drug Design
Enzyme Inhibitors--pharmacology
Female
Fibroblasts--drug effects
Gene Products, tat--genetics
HSP90 Heat-Shock Proteins--genetics
HeLa Cells
Homeodomain Proteins--genetics
Humans
Inhibitor of Apoptosis Proteins
Lactams, Macrocyclic
Male
Mice
Mice, SCID
Microtubule-Associated Proteins--metabolism
Models, Molecular
Molecular Mimicry
Neoplasm Proteins
Nuclear Proteins--genetics
Peptide Fragments--chemistry
Prostatic Neoplasms--drug therapy
Protein Binding--drug effects
Protein Conformation
Proto-Oncogene Proteins c-bcl-2--genetics
Rifabutin--analogs & derivatives
Stem Cells--drug effects
Survivin
Telomerase--metabolism
Transcription Factors--genetics
Tumor Suppressor Protein p53--genetics
Xenograft Model Antitumor Assays