Direct measurement of nucleoside monophosphate delivery from a phosphoramidate pronucleotide by stable isotope labeling and LC-ESI(-)-MS/MS.

Kim, Jisook

Direct measurement of nucleoside monophosphate delivery from a phosphoramidate pronucleotide by stable isotope labeling and LC-ESI(-)-MS/MS. [electronic resource] - Molecular pharmaceutics - 102-11 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

1543-8384

10.1021/mp0340338 doi


Amides
Biological Transport
Cell Line, Tumor
Chromatography, High Pressure Liquid
Dideoxynucleotides
Drug Carriers
Humans
Isotope Labeling--methods
Oxygen--pharmacokinetics
Oxygen Isotopes
Phosphoric Acids
Ribonucleotides--pharmacokinetics
Spectrometry, Mass, Electrospray Ionization
Thymine Nucleotides--pharmacokinetics
Zidovudine--analogs & derivatives