Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein.

Schwarz, Jacob B

Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein. [electronic resource] - Journal of medicinal chemistry Apr 2005 - 3026-35 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm0491086 doi


Administration, Oral
Amines--chemical synthesis
Amino Acid Transport System L--metabolism
Amino Acids--chemistry
Animals
Anticonvulsants--chemical synthesis
Biological Transport, Active
Blood-Brain Barrier--metabolism
CHO Cells
Calcium Channels--drug effects
Cricetinae
Cricetulus
Cyclization
Cyclohexanecarboxylic Acids--chemical synthesis
Cyclopropanes--chemical synthesis
Gabapentin
In Vitro Techniques
Injections, Intraventricular
Ion Channel Gating
Male
Mice
Mice, Inbred DBA
Nitriles--chemistry
Pregabalin
Protein Subunits--metabolism
Rats
Rats, Sprague-Dawley
Swine
gamma-Aminobutyric Acid--analogs & derivatives