Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis.

Grygielko, Eugene T

Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. [electronic resource] - The Journal of pharmacology and experimental therapeutics Jun 2005 - 943-51 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3565

10.1124/jpet.104.082099 doi


Activin Receptors--antagonists & inhibitors
Animals
Biomarkers
Cell Line, Tumor
Collagen Type I--genetics
Dose-Response Relationship, Drug
Fibrosis
Humans
Kidney--pathology
Nephritis--metabolism
Phosphorylation
Plasminogen Activator Inhibitor 1--genetics
Protein Serine-Threonine Kinases--antagonists & inhibitors
Puromycin--toxicity
RNA, Messenger--analysis
Rats
Rats, Sprague-Dawley
Receptor, Transforming Growth Factor-beta Type I
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta--antagonists & inhibitors
Transforming Growth Factor beta1