Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8.

Arbel-Goren, Rinat

Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8. [electronic resource] - The Journal of biological chemistry May 2005 - 19105-14 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M502060200 doi


Androstadienes--pharmacology
Animals
Anthracenes--pharmacology
Apoptosis
Blotting, Northern
Blotting, Western
Bromodeoxyuridine--pharmacology
CHO Cells
Cell Adhesion
Cell Cycle Proteins--metabolism
Cell Line, Tumor
Cell Proliferation
Cricetinae
Cyclin-Dependent Kinase Inhibitor p21
Cycloheximide--pharmacology
DNA--metabolism
Galectins--metabolism
Green Fluorescent Proteins--metabolism
Humans
JNK Mitogen-Activated Protein Kinases--metabolism
Ligands
MAP Kinase Kinase 4
Mitogen-Activated Protein Kinase Kinases--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Poly(ADP-ribose) Polymerases--metabolism
Protein Kinase Inhibitors--metabolism
Protein Synthesis Inhibitors--pharmacology
RNA, Messenger--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Thymidine--pharmacology
Time Factors
Up-Regulation
Wortmannin